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Palmitoylethanolamide (PEA)
CAS Number: 544-31-0
Purity: 99% by HPLC
Synonyms:
Palmitamide MEA
N-Hydroxyethyl Palmitamide
Pamiol
Описание
маркер
Palmitoylethanolamide (PEA)
- CAS Number: 544-31-0
- Purity: 99% by HPLC
- Synonyms:
- Palmitamide MEA
- N-Hydroxyethyl Palmitamide
- Pamiol
PEA is available in various forms, including as a dietary supplement. As a lipid amide, it plays a significant role in cell signaling and the regulation of inflammatory processes. Its primary therapeutic benefit lies in its potential to control chronic pain and inflammatory conditions through natural mechanisms, offering a promising alternative for individuals seeking non-psychoactive, natural options.
Chemical Structure and Mechanism of Action
PEA is a fatty acid amide that is structurally related to endocannabinoids, specifically anandamide. It activates PPAR-α, a receptor involved in the modulation of pain and inflammation. Upon activation of PPAR-α, PEA helps to:
- Reduce inflammation: By inhibiting pro-inflammatory cytokines.
- Modulate pain pathways: Through interactions with ECS receptors, PEA helps alleviate chronic pain, particularly pain associated with inflammation and neurodegenerative diseases.
Unlike cannabinoids like THC, PEA does not bind directly to CB1 or CB2 receptors, thus lacking psychoactive effects.
Health Benefits of PEA
- 1.Anti-Inflammatory and Analgesic Effects
PEA has been extensively studied for its ability to relieve chronic pain and inflammation, making it a valuable option for individuals dealing with:
- Chronic pain conditions(such as fibromyalgia, neuropathic pain)
- Musculoskeletal inflammation
- Osteoarthritis
PEA works by interacting with PPAR-α, which reduces the release of inflammatory mediators, thus easing pain and inflammation in affected tissues.
- 2.Chronic Pain Management
One of the major uses of PEA is in the management of chronic pain. Studies have shown that it is effective in reducing pain intensity in various conditions, including back pain, nerve pain, and joint pain. Unlike traditional painkillers, PEA provides a natural, non-addictive alternative for pain management.
- 3.Neuroprotective Effects
PEA has shown potential in protecting neurons from damage due to oxidative stress and inflammation. Its neuroprotective properties make it a candidate for treating conditions such as Alzheimer's disease and Parkinson's disease, where inflammation plays a key role in the progression of the disease.
- 4.Mood and Cognitive Benefits
Research indicates that PEA may also have mood-enhancing effects by reducing depressive symptoms and enhancing cognitive function. This is partly due to its action on the ECS, which is involved in the regulation of mood, stress responses, and overall mental health. It has been shown to reduce anxiety and improve emotional well-being in animal models and clinical trials.
PEA in Organic Synthesis and Pharmaceutical Development
Besides its role as a health supplement, PEA is also a significant intermediate in organic synthesis. It is used in:
- Pharmaceutical development: As a precursor for drugs targeting pain and inflammation.
- Chemical research: To study the effects of endocannabinoid-like compounds on the body.
PEA has potential applications in drug development, particularly in the creation of anti-inflammatory and analgesic drugs. Research is ongoing to explore its full range of pharmacological properties.
Applications and Industry Use
- 1.Dietary Supplements: PEA is often used in the form of capsules or tablets, especially for its anti-inflammatoryand pain-relieving It has gained popularity as a natural alternative to over-the-counter and prescription pain relievers.
- 2.Pharmaceutical Industry: PEA's use as a pharmaceutical intermediate has led to its incorporation in experimental treatments for conditions like chronic pain, neurodegenerative diseases, and inflammatory disorders.
- 3.Cosmetic Industry: Due to its anti-inflammatory and skin-healing properties, PEA is sometimes used in cosmetic formulationsdesigned to soothe and protect the skin.
Scientific Studies and Evidence Supporting PEA
Recent studies highlight the growing interest in PEA for its therapeutic benefits. Some significant findings include:
- Chronic Pain Relief: In clinical trials, PEA has been shown to reduce pain in patients with conditions like chronic back painand muscle inflammation.
- Anti-Inflammatory Effects: Studies have demonstrated that PEA can inhibit the release of pro-inflammatory cytokines, offering significant anti-inflammatory benefits for various diseases.
- Neuroprotective Effects: PEA’s ability to activate PPAR-αreceptors has been linked to its neuroprotective properties, suggesting a potential role in treating neurodegenerative diseases like Alzheimer's and Parkinson's.
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