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Oxidized L-Glutathione
- Oxidized Glutathione (GSSG)
- CAS Number: 121-24-4
- Purity: 98%-102% by HPLC
- Derivative: Acetylated Glutathione
Описание
маркер
- Oxidized Glutathione (GSSG)
- CAS Number: 121-24-4
- Purity: 98%-102% by HPLC
- Derivative: Acetylated Glutathione
- Appearance: White powder
- Solubility: Soluble in water, insoluble in ethanol and ether
- Solution Color: Colorless to light yellow, clear and transparent in aqueous solution
- Stability: Highly stable in its natural state
Key Functions and Benefits of Oxidized Glutathione (GSSG):
Oxidized Glutathione (GSSG) is the oxidized form of the antioxidant molecule glutathione (GSH). It plays a vital role in cellular defense mechanisms against oxidative stress and is involved in numerous biochemical processes in the human body. Here's a detailed breakdown of its functions:
- 1.Antioxidant Protection and Redox Balance:
- Redox Role: GSSG is crucial in maintaining the oxidation-reduction (redox) balancein cells. It acts as an electron carrier in various biochemical reactions, participating in electron transfer within biological systems. When oxidized, glutathione (GSSG) converts back to its reduced form (GSH), which helps neutralize free radicals, reactive oxygen species (ROS), and other harmful oxidants .
- Cellular Protection: GSSG plays a protective role in preventing oxidative damage to red blood cells. It helps maintain the reduced state of hemoglobin cysteine, which is essential for maintaining healthy red blood cells and proper hemoglobin function.
- 2.Enzyme Activation and Function Restoration:
- SH Group Protection: One of the key benefits of GSSG is its ability to protect the -SH (sulfhydryl) groupsof enzyme molecules. These sulfur-containing groups are crucial for enzyme activity, and by protecting them, GSSG ensures the proper functioning of enzymes. Furthermore, GSSG helps restore the activity of enzymes whose -SH groups may have been damaged by oxidative stress or external factors .
- Reactivation of Damaged Enzymes: GSSG can reactivate enzymes that have lost their functionality due to oxidative damage. This process helps restore critical biochemical functions, especially in detoxification and metabolic pathways.
- 3.Liver Protection and Fatty Liver Prevention:
- Protection Against Ethanol: GSSG has shown potential in protecting the liver from oxidative damage caused by ethanol consumption, which is a common contributor to liver damage and diseases such as fatty liver. By neutralizing oxidative stress, GSSG helps maintain healthy liver function.
- Fatty Liver Disease: GSSG is associated with the prevention of fatty liverformation by promoting antioxidant defenses in the liver, reducing oxidative damage, and preventing the accumulation of fat in liver cells. This makes it a valuable molecule for maintaining liver health and preventing liver diseases.
- 4.Detoxification and Heavy Metal Removal:
- Detoxification Agent: One of the most important roles of GSSG is in the detoxification of harmful substances. It combines with toxic compounds, heavy metal ions, and carcinogens, facilitating their elimination from the body. This detoxifying action is essential in reducing the toxic burden on the body, enhancing general health, and preventing the accumulation of harmful substances.
- Heavy Metal Detox: GSSG plays an essential role in neutralizing heavy metals and aiding in their excretion from the body, particularly lead, mercury, and cadmium. These metals can otherwise accumulate in tissues and cause long-term health issues, including neurological and kidney damage.
- 5.Immune System Support:
- Immune Function: As a potent antioxidant, GSSG supports the immune systemby neutralizing free radicals and reducing oxidative stress that can weaken immune cells. Additionally, by maintaining a favorable redox environment, GSSG helps ensure optimal function of immune cells such as T-cells and macrophages, which are critical for immune defense .
- Cancer Prevention: Due to its detoxifying properties, GSSG may also assist in cancer preventionby reducing oxidative damage to DNA and neutralizing carcinogens that could otherwise contribute to cancer cell mutation and growth.
- 6.General Health Benefits:
- Anti-aging Effects: GSSG is often associated with anti-aging benefits, as it helps reduce oxidative stress, which is a key contributor to aging and the development of age-related diseases such as Alzheimer's and cardiovascular diseases. By protecting cellular components, GSSG helps maintain youthful function and resilience.
- Skin Health: Antioxidants like GSSG are beneficial for skin health. They protect skin cells from oxidative damage caused by UV exposure, pollution, and environmental stressors, helping to maintain youthful and healthy skin.
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