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Nattokinase

Nattokinase
CAS Number: 133876-92-3
Purity: 99% by HPLC
Source: Extracted from Natto (fermented soybeans) or produced by Bacillus subtilisnatto.

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Nattokinase

CAS Number: 133876-92-3
Purity: 99% by HPLC
Source: Extracted from Natto (fermented soybeans) or produced by Bacillus subtilisnatto

Function & Benefits of Nattokinase:

Nattokinase (NK) is a potent fibrinolytic enzyme extracted from the Japanese food natto, which is made from fermented soybeans. It plays a crucial role in breaking down fibrin, the protein responsible for blood clot formation, and has been studied for its cardiovascular and health benefits.

Key Features:

Molecular Size: Nattokinase is a smaller protein compared to other fibrinolytic agents like UK (urokinase), SK (streptokinase), and tPA (tissue plasminogen activator). Its small size allows for easier absorption in the intestines.
Fibrinolytic Activity: Nattokinase has been shown to exhibit strong fibrinolytic activity both in vitro (in lab experiments) and in vivo (in the body). It is reported to be four times more effectivein breaking down fibrin compared to plasmin, the body's natural fibrinolytic enzyme.

Mechanism of Action:

In Vivo Action: After absorption, nattokinase acts quickly in the body, with a prolonged effect. It helps to activate the body's natural tPA, increasing the fibrinolytic activity in a controlled and sustained manner. This mechanism allows nattokinase to gradually enhance the body’s ability to dissolve blood clots, improving circulation and reducing the risk of thrombosis .
Increased tPA Activation: Nattokinase helps activate tPA, enhancing its ability to break down fibrin in the blood. This effect supports cardiovascular health by promoting better blood flow and reducing clot formation .

Potential Health Benefits:

Improved Circulation & Blood Flow: By breaking down fibrin, nattokinase helps reduce the risk of blood clots, promoting better circulation throughout the body.
Prevention of Cardiovascular Disease: Regular intake of nattokinase is associated with a lower risk of heart disease, as it helps to prevent the formation of blood clots that can lead to strokes, heart attacks, and other cardiovascular issues .
Lower Blood Pressure: Studies have suggested that nattokinase can contribute to lowering high blood pressure, likely due to its role in improving blood flow and reducing clot formation.
Thrombosis Treatment: Due to its ability to dissolve fibrin clots, nattokinase has been explored as a potential treatment for thrombosis (the formation of abnormal blood clots in blood vessels) .

Clinical Applications:

Nattokinase has been used in a variety of therapeutic applications, particularly in the following fields:

Cardiovascular Health: Used in supplements aimed at improving heart health, blood circulation, and preventing clots.
Stroke Prevention: Some studies suggest that nattokinase supplementation may reduce the risk of stroke by preventing clot formation and improving fibrinolytic activity .

Blood Pressure Regulation: Nattokinase may help reduce systolic and diastolic blood pressure by preventing clot formation and improving vascular health.

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